Naltrexone hydrochloride
Naltrexone hydrochloride
CAS: 16676-29-2
Molecular Formula: C20H24ClNO4
Naltrexone hydrochloride - Names and Identifiers
| Name | Naltrexone hydrochloride |
| Synonyms | Naltrexone hcl NALTREXONE HYDROCHLORIDE Naltrexone hydrochloride N-CYCLOPROPYLMETHYL-14-HYDROXYDI-HYDROMORPHINONE HYDROCHLORIDE 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-morphinan-6-onhydrochlor 17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onhydr 17-(cyclopropylmethyl)-4,5-alpha-oxy-3,14-dihydoxy-morphinan-6-onhydrochlo 17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onehydroch (5A)-17-(CYCLOPROPYLMETHYL)-4,5-EPOXY-3,14-DIHYDROMORPHINAN-6-ONE HYDROCHLORIDE (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride (5alpha)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride (5alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride |
| CAS | 16676-29-2 |
| EINECS | 240-723-0 |
| InChI | InChI=1/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1 |
Naltrexone hydrochloride - Physico-chemical Properties
| Molecular Formula | C20H24ClNO4 |
| Molar Mass | 377.86 |
| Melting Point | 274-2760C |
| Boling Point | 558.1°C at 760 mmHg |
| Flash Point | 291.4°C |
| Water Solubility | Soluble in water at 50mg/ml. |
| Solubility | H2O: 50mg/mL, clear, colorless |
| Vapor Presure | 2.71E-13mmHg at 25°C |
| Appearance | neat |
| Color | White to Off-White |
| Merck | 13,6389 |
| BRN | 3580333 |
| Storage Condition | 2-8°C |
| Sensitive | Light Sensitive |
| In vivo study | In macaques, Naltrexone (0.32 mg/kg) attenuated the ethanol-enhanced response at the concentration that maintained the highest response (1% or 2%). Naltrexone (0.1 mg/kg) at a low ethanol concentration (0.25%) yielding a small ethanol uptake (g/kg) and at a high ethanol concentration (4%) yielding a modest amount of uptake weakens the ethanol-enhanced response. Naltrexone (1-3 mg/kg) potently and dose-dependently inhibited the ethanol demand generated by the non-accidental delivery of 8% ethanol-filled liquid scoops. When Naltrexone (approximately 100 ng/kg) was co-administered with morphine (3 mg/kg), the analgesic efficacy of morphine was optimally amplified. In the rat tail-flick test, Naltrexone (10 ng/kg I. p.) enhanced morphine acute submaximal dose intracapsular (5 mg) or systemic (7.5 mg/kg I. p.) analgesic effect of drug administration. In rats, Naltrexone in combination with morphine inhibits the attenuation of morphine analgesia and prevents the loss of morphine efficacy. Naltrexone significantly inhibited ethanol self-administration and prevented the ethanol-induced increase in osmotic dopamine levels. Naltrexone completely prevented the reduction of the distance between the anus and the genitals in prenatal stress (PS) males and restored the growth rate of both sexes. Naltrexone also reduced anxiety in PS rats in the cross maze, increasing the measured opioid component to control levels, but increasing anxiety in control men. |
Naltrexone hydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | QD2160000 |
| FLUKA BRAND F CODES | 8-10 |
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Spot supply
Product Name: Nalbuphine Impurity 5 Visit Supplier Webpage Request for quotationCAS: 16676-29-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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